In the summer of 1880, many people are traveling to the booming health resort of Manitou Springs, Colorado, at the foot of Pike's Peak, to "chase the cure" for tuberculosis. But Inez Stannert, part-owner of the Silver Queen Saloon in Leadville, travels for a different reason. After a long separation, she's reuniting with her young son, William, and her beloved sister, Harmony. However, the stagecoach journey to Manitou turns deadly when East Coast businessman Edward Pace mysteriously dies under the horrified gaze of Inez and Pace's wife and children. After they arrive at the posh Mountain Springs House hotel, Pace's widow begs Inez to make inquiries into her husband's untimely death.